Triple negative tumors accumulate significantly less methylglyoxal specific adducts than other human breast cancer subtypes

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Triple negative tumors accumulate significantly less methylglyoxal specific adducts than other human breast cancer subtypes

Metabolic syndrome and type 2 diabetes are associated with increased risk of breast cancer development and progression. Methylglyoxal (MG), a glycolysis by-product, is generated through a non-enzymatic reaction from triose-phosphate intermediates. This dicarbonyl compound is highly reactive and contributes to the accumulation of advanced glycation end products. In this study, we analyzed the ac...

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Triple-negative breast cancer: distinguishing between basal and nonbasal subtypes.

PURPOSE Triple-negative (TN; estrogen receptor, progesterone receptor, and HER-2 negative) cancer and basal-like breast cancer (BLBC) are associated with poor outcome and lack the benefit of targeted therapy. It is widely perceived that BLBC and TN tumors are synonymous and BLBC can be defined using a TN definition without the need for the expression of basal markers. EXPERIMENTAL DESIGN We h...

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ژورنال

عنوان ژورنال: Oncotarget

سال: 2014

ISSN: 1949-2553

DOI: 10.18632/oncotarget.2121